Aim. To evaluate the efficacy and safety of the use of KARMOLIS® DROPS in the rehabilitation of patients after COVID-19 infection. Material and methods. The study included and completed observation of 40 medical staff aged 20 to 60 years who had suffered from COVID-19 in a moderate to severe form. The follow-up period was 21 days. The study participants were divided into two groups. The main group (20 people) received KARMOLIS® DROPS. The control group (20 people) treatment was carried out without the use of KARMOLIS® DROPS. The effectiveness was evaluated according to a set of clinical and functional indicators. Results and discussion. Against the background of taking KARMOLIS® DROPS, reliable positive dynamics of the subjective assessment of shortness of breath (MRC scale) and the subjective assessment of sleep quality (Vane A.M. scale) were recorded in the main group. Subjective efficacy of the studied KARMOLIS ® DROPS was noted by almost all patients who underwent treatment, which is probably due to improved sleep and well-being by reducing autonomic reactions. Taking into account the data obtained during the study, KARMOLIS® DROPS can be used in the recovery process after COVID-19 as a component of comprehensive rehabilitation. Conclusion. The safety of using the herbal medicine KARMOLIS® DROPS was confirmed by the absence of adverse events and cases of decompensation of concomitant diseases during the study. Patients’ emotionally positive perception of the drug ensured its high compliance.
acute respiratory infection, COVID-19, postcovid syndrome, respiratory function, psycho-emotional background, shortness of breath, sleep quality, vegetative disorders, phytotherapy, Karmolis
1. Carda S., Invernizzi M., Bavikatte G., Bensmaïl D., Bianchi F., Deltombe T., Draulans N., Esquenazi A., Francisco G.E., Gross R., Jacinto L.J., Moraleda Pérez S., O’Dell M.W., Reebye R., Verduzco-Gutierrez M., Wissel J., Molteni F. The role of physical and rehabilitation medicine in the COVID-19 pandemic: The clinician’s view. Annals of Physical and Rehabilitation Medicine. 2020; 63(6): 554-556. https://doi.org/10.1016/j.rehab.2020.04.001
2. Profilaktika, diagnostika i lechenie novoy koronavirusnoy infekcii (COVID-19). Minzdrav Rossii. Vremennye metodicheskie rekomendacii: Versiya 10. 08.02.2021.
3. Razumov A.N., Ponomarenko G.N., Badtieva V.A. Medicinskaya reabilitaciya pacientov s pnevmoniyami, associirovannymi s novoy koronavirusnoy infekciey COVID-19. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul'tury. 2020; 97(3): 5-13. https://doi.org/10.17116/kurort2020970315
4. National Institute for Health and Care Excellence, Royal College of General Practitioners, Healthcare Improvement Scotland SIGN. COVID-19 rapid guideline: managing the long-term effects of COVID-19. London: National Institute for Health and Care Excellence. 2020. Available at: https://www.nice.org.uk/guidance/ng188
5. Vorob'ev P.A. Rekomendacii po vedeniyu bol'nyh s koronavirusnoy infekciey COVID-19 v ostroy faze i pri post-kovidnom sindrome v ambulatornyh usloviyah. Problemy standartizacii v zdravoohranenii. 2021; (7-8): 3-96. https://doi.org/10.26347/1607-2502202107-08003-096
6. Gosudarstvennyy Reestr lekarstvennyh sredstv. Dostupno na: https://zdravmedinform.ru/grls.html. (data obrascheniya 13.10.21).
7. Registracionnoe udostoverenie lekarstvennogo preparata dlya medicinskogo primeneniya “KARMOLIS kapli” PN 015043/01 Minzdravsocrazvitiya. 2008. Dostupno na: https://www.rlsnet.ru/tn_index_id_35592.htm
8. Issledovanie protivovirusnoy aktivnosti preparata “Karmolis kapli” v otnoshenii virusov grippa i drugih ostryh respiratornyh zabolevaniy. Otchet o NIR NII grippa RAMN. 2004: 8 s. Dostupno na: https://carmolis.ru/assets/images/articles/gripp/gripp11.pdf
9. Mar'in G.G., Akimkin V.G., Salmina T.A., Suhova V.A. Profilakticheskaya i farmakoekonomicheskaya effektivnost' primeneniya lekarstvennyh rastitel'nyh sredstv pri streptokokkovyh infekciyah v organizovannyh voinskih kollektivah. Epidemiologiya i infekcionnye bolezni. 2013; (6): 32-8
10. Sahu A.K., Amrithanand V.T., Mathew R., Aggarwal P., Nayer J., Bhoi S. COVID-19 in health care workers - A systematic review and meta-analysis. The American Journal of Emergency Medicine. 2020; 38(9): 1727-1731. https://doi.org/10.1016/j.ajem.2020.05.113
11. Makarova M.R., Lyamina N.P., Somov D.A., Turova E.A., Rassulova M.A., Pogonchenkova I.V., Schikota A.M. Fizicheskaya reabilitaciya pri pnevmonii, associirovannoy s COVID-19. Uchebno-metodicheskoe posobie. Moskva. 2020.
12. Pogonchenkova I.V., Belevskiy A.S., Mescheryakova N.N., Makarova M.R., Rassulova M.A., Schikota A.M., Starodubova A.V., Somov D.A., Turova E.A., Kukshina A.A., Kotel'nikova A.V., Livancova E.N., Varaeva Yu.N., Egorova V.V., Brumberg A.A. Medicinskaya reabilitaciya pacientov s vnebol'nichnoy pnevmoniey, associirovannoy s novoy koronavirusnoy infekciey (COVID-19). Metodicheskie rekomendacii. Moskva. 2021.
13. Veyn A.M. Medicina sna. Izbrannye lekcii po nevrologii. M. Eydos Media. 2006: 12-20.
