Bulletin of Rehabilitation Medicine Bulletin of Rehabilitation Medicine Вестник восстановительной медицины 2078-1962 2713-2625 68977 10.38025/2078-1962-2022-21-5-109-115 Технологии восстановительной медицины и медицинской реабилитации Rehabilitation Medicine and Medical Rehabilitation Technologies Технологии восстановительной медицины и медицинской реабилитации Health Resort Detox Programs Impact on the Body: a Prospective Laboratory Analysis in «Kivach Clinic» Проспективный анализ влияния санаторно-курортных детокс-программ на организм в «Клинике Кивач» с учетом лабораторных показателей https://orcid.org/0000-0001-8130-9517 Исаев Ф. И. Isayev. Fedor I. https://orcid.org/0000-0002-3248-1633 Москалев А. А. Moskalev. Alexey A. ЗАО «Клиника Кивач», Кончезеро, Республика Карелия, Россия ru ЗАО «Клиника Кивач», Кончезеро, Республика Карелия, Россия ru Федеральный исследовательский центр «Коми научный центр Уральского отделения Российской академии наук, Сыктывкар, Россия ru Федеральный исследовательский центр «Коми научный центр Уральского отделения Российской академии наук, Сыктывкар, Россия ru Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия ru Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия ru 25 10 2022 25 10 2022 21 5 109 115 12 10 2022 20 10 2022 https://nmicrk.editorum.ru/en/nauka/article/68977/view

ВВЕДЕНИЕ. Не было проведено ни одного исследования влияния на организм человека санаторно-курортных детокс-программ, основанных на терапевтическом управлении дренажем лимфатических тканей, на метаболизм человека и возможность снижения уровня интоксикации и воспаления. ЦЕЛЬ. Предпринять первую попытку объективной оценки влияния санаторно-курортных программ детоксикации организма на липидный и углеводный обмен, процессы интоксикации и воспаления. МАТЕРИАЛ И МЕТОДЫ. Лабораторные данные были получены для всех пациентов, проходивших лечение по программе детоксикации в соответствующем диапазоне дат (у 89 человек венозная кровь была взята в первый день и за день до отъезда). Рассчитана динамика лабораторных показателей. РЕЗУЛЬТАТЫ И ОБСУЖДЕНИЕ. Отмечается повышение маркеров интоксикации к концу первой недели и снижение маркеров воспаления и интоксикации к концу второй, сопровождающееся снижением уровня общего холестерина. Показатель HOMA снижается во всех группах, но другие маркеры инсулинорезистентности остаются неизменными. Снижение уровня холестерина подтверждает ожидаемый эффект лимфодренажа и потери желчных кислот. Наблюдается снижение печеночной инсулинорезистентности без существенного изменения общей. Подтвержден процесс нарастания аутоинтоксикации во время лимфодренажа и ее дальнейшее снижение ниже исходных значений. ЗАКЛЮЧЕНИЕ. Предпринята попытка оценить программы детоксикации организма с помощью лабораторных маркеров. Такие программы снижают уровень общего холестерина, уровень интоксикации организма и воспаления, снижают печеночный компонент инсулинорезистентности. Это воздействие происходит поэтапно.

INTRODUCTION. The impact on a human organism of health resort detox programs based on therapeutic governance of lymphatic tissues drainage on human metabolism and a possibility to reduce intoxication and inflammation level has not been evaluated yet. AIM. To make the first attempt to objectively estimate the influence of health resort body detoxification programs on lipid and carbohydrate metabolism and the processes of intoxication and inflammation. MATERIAL AND METHODS. The laboratory data were obtained for all the patients treated under the detoxication program in the corresponding date range (89 persons had a venous blood collected on the first day and the day before the departure). The dynamics of the laboratory indicators were calculated. RESULTS AND DISCUSSION. There is an increase of intoxication markers to the end of the first week and a decrease of inflammation and intoxication markers to the end of the second accompanied by a decrease in total cholesterol level. HOMA decreases in all groups, but other insulin resistance markers remain unaltered. The decrease in cholesterol confirms the expected effect of lymphatic drainage and bile acid loss. There is a decrease in the hepatic insulin resistance without a significant change of the total one. The process of autointoxication rising during the lymphatic drainage and its further decline below the start values is confirmed. CONCLUSION. An attempt was made to evaluate the body's detoxification programmes using laboratory markers. Such programs decrease level of total cholesterol, body’s intoxication and inflammation level, lower hepatic component of the insulin resistance. This impact is in stages.

 загрязнители окружающей среды сорбционная детоксикация курорты липидный обмен углеводный обмен воспаление инсулинорезистентность environmental pollutants sorption detoxification health resorts lipid metabolism carbohydrate metabolism inflammation insulin resistance

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